Endocrine Abstracts

Background: Glucose-dependent insulinotropic polypeptide (GIP) is a gastrointestinal hormone that is secreted in response to food intake. GIP acts on various tissues, including pancreatic ß-cells, via interaction with its G-protein-coupled receptor. Some studies in rodents suggested that GIP directly links overnutrition to obesity. GIP exerts a physiological role on lipid uptake into adipocytes.Objectives: To analyse the effect of GIP-Infusions on c...

Background: Glucose-dependent insulinotropic polypeptide (GIP) is a gastrointestinal hormone that is secreted in response to food intake and modulates β-cell function. Remarkably, GIP looses its insulinomimetic effect in the presence of chronic hyperglycaemia and thus appears to be ineffective in poorly controlled T2DM at least with regard to insulin release. The mechanism by which this occurs is not clear and it is not known.Objectives: To analyse ...